Overall survival among SCT patients with multiple myeloma has improved between 2013 and 2022
This Finnish registry-based study investigated the development of treatment practices and patient outcomes between 2013 and 2022.
Study summaries
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Asthma and Antibiotic Use Increase the Risk of Revision Surgery in CRSwNP Patients
Asthma and antibiotic use are linked to a higher risk of revision surgery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This finding is based on a real-world evidence (RWE) study published in February.
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Prostate Cancer Study Successfully Linked Deep Clinical Hospital Data with Broader Healthcare Data
A real-world evidence (RWE) study on the treatment of metastatic castration-resistant prostate cancer (mCRPC) has provided new insights into the therapeutic strategies for mCRPC. The analysis was based on data from 2,500 patients treated in Finland.
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Lymphoma Project by the University of Eastern Finland and Medaffcon Generates Over Ten Publications
The lymphoma research project has proven to be an exceptionally versatile source of new knowledge. The project includes at least two doctoral researchers, and its results are expected to generate well over ten scientific articles.
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Extensive Finnish Study Offers New Insights into Infection Risk and Mortality in Multiple Myeloma
Multiple myeloma significantly increases the risk of infections. A recent real-world evidence (RWE) study revealed that multiple myeloma (MM) patients experience more infections compared to healthy controls, even prior to diagnosis. Infections, both before and after diagnosis, were associated with an increased mortality.
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RWE Study: Chronic Kidney Disease often goes undiagnosed
Despite its high-risk nature and availability of kidney treatments, chronic kidney disease (CKD) often goes undiagnosed. This especially concerns patients without type 2 diabetes (T2D), who represent the majority of CKD patients. This finding comes from a recent registry study published in Nephrology Dialysis Transplantation (NDT).
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Prognosis for Multiple Myeloma has Improved, but Prevalence is Increasing
The prognosis for patients with multiple myeloma (MM) has improved as treatments have advanced, but the disease remains incurable. The prevalence of the disease is increasing in Finland as the population gets older. This is evident from a recently published nationwide retrospective study based on real-world evidence (RWE).
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New Diabetes Medications Were Actively Adopted Between 2012–2019 – The Results Are Promising
The adoption of new diabetes medications in Finland was active between 2012 and 2019, according to an RWE (Real World Evidence) study published in May 2024. The study was conducted by Medaffcon in collaboration with the pharmaceutical company Sanofi.
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New RWE Study Indicates Poor Prognosis for NSCLC Patients Despite Targeted Therapies
Lung cancer is the leading cause of cancer deaths in Finland, with a particularly poor prognosis for non-small cell lung cancer (NSCLC). It is often diagnosed at an advanced stage when treatment options are limited. A recently published retrospective registry-based real-world evidence (RWE) study on KRAS-mutated NSCLC patients in Finland addressed this issue.
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New RWE study indicates significant potential for improvement in treating adults with Short Bowel Syndrome (SBS-IF)
A study published in January 2024 in the Scandinavian Journal of Gastroenterology has revealed that the treatment of adults with Short Bowel Syndrome (SBS-IF) clearly has significant room for improvement.
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Finnish hospital data lakes can be adapted to analysis of complex treatment patterns, outcomes and healthcare burden in multiple myeloma
Our latest multiple myeloma publication describes how complex multiple myeloma treatment patterns were assembled from data available in the Helsinki University Hospital data lake, Finland, how the treatments have changed in 2013–2019, and what the estimated treatment costs are in multiple myeloma.The study published online in October 2023 was carried out by the experts at Medaffcon Oy, Sanofi Oy, and Helsinki University Hospital, Finland.
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The introduction of new medications has resulted in a change in the treatment of advanced renal cell carcinoma in Southwest Finland
Utilising the data lake of the Hospital District of Southwest Finland (TYKS), Medaffcon, Pfizer and TYKS have examined the clinical adoption of new medications for advanced renal cell carcinoma and the utility of data extracted without extensive manual extraction.
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Manual extraction gathered information on the drug treatment for ulcerative colitis
Hospital data lakes are a central source of information in Medaffcon's studies, and often, data retrieval can be automated. However, what happens when more complex matters need to be extracted from the databases? In such cases, manual extraction is used, says Medaffcon's Scientific Advisor, Riikka Mattila
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Characteristics of T2-low asthma revealed with Finnish real-world data
AstraZeneca Finland, Medaffcon and clinical experts have investigated what is the rarer endotype of severe asthma using biomarker data obtained from the data lake of Turku University Hospital (TYKS), Auria.
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Medaffcon’s matching know-how on display in immunosuppressant study
Samuli Tuominen, senior data scientist at Medaffcon, has co-authored a study that utilised propensity-score matching to compare the performance of two immunosuppressive drugs in patients with primary sclerosing cholangitis after liver transplantation. Medaffcon has helped to validate the superiority of tacrolimus over cyclosporine as a post-liver transplantation immunosuppressive regimen for patients with primary sclerosing cholangitis, a rare immune-mediated cholestatic liver disease.
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Atopic dermatitis is often under-treated despite various co-morbidities, reveal real-world data
Experts at Medaffcon have perused volumes of real-world data on patients with atopic dermatitis to provide new insights into co-morbidities and treatment patterns associated with the chronic skin condition.
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Finnish healthcare data helps cast light on burden of paediatric short-bowel syndrome
Experts from Medaffcon, Takeda and the Hospital District of Helsinki and Uusimaa (HUS) have concluded an extensive study into paediatric short-bowel syndrome based on information from patient records.
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Multiregister study in monitoring the burden of sexually transmitted diseases in Finland
Our first national multiregister study on sexually transmitted diseases provides important information on the burden of genital warts (GWs) in Finland.
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Short-term sick leaves accentuated in chronic diseases – register studies provide new information
Studies mapping short-term absences provide new information on the burden caused by diseases for healthcare services and the society.
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Smoking clearly increases the risk of postoperative complications
Register study undisputedly confirms that a smoker’s risk for any postoperative complications is significantly higher than non-smokers’.
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New study: Treatment costs of heart failure increase tenfold in exacerbation
The result of a recent original study surprised the researchers: the costs of treating heart failure tenfold in exacerbation. The results were published in Duodecim on 23 March 2023.
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The burden of Chronic Rhinosinusitis with Nasal Polyps and its relation to Asthma in Finland
In this nationwide register study, we described the incidence, prevalence, and treatment burden of chronic rhinosinusitis with nasal polyps (CRSwNP), and its disease association with asthma from 2012 to 2018 in Finland.
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Comorbidity characteristics of multiple myeloma patients diagnosed in Finland 2005-2016
Our recent RWE study detailed the comorbidity burden of Finnish multiple myeloma (MM) patients diagnosed between 2005 and 2016.
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Gaucher study provides new aspects in rare disease screening and the utilization of data and specimens of the Finnish biobanks
The study assessed the prevalence of Gaucher disease in Finland and developed methods to screen...
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Cardiovascular outcome according to renal status in Finnish patients with type 2 diabetes
Chronic kidney disease has been suggested as the main contributor to the increased cardiovascular morbidity...
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Patients with atherosclerotic cardiovascular disease are at high risk of death after the first cardiovascular event, shows a Finnish real-world evidence study
Cardiovascular diseases are the leading cause of disability and premature death worldwide. Real-world evidence (RWE)...
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Utilisation of Finnish hospital data lake data to analyse diffuse large B-cell lymphoma (DLBCL) in a real-world setting: Recording practices at routine care should be developed
Real-world data on diffuse large B-cell lymphoma (DLBCL) has remained incomplete. In Finland, electronic health...
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Hip and knee osteoarthritis more than doubles the number of sick leave days and occupational healthcare contacts for working age individuals
Research has shown that osteoarthritis causes disability, especially among older adults. Our latest real-world evidence...
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Characteristics and survival trends in Finnish multiple myeloma patients—a nationwide real-world evidence study
Multiple myeloma (MM) is a hematologic cancer displaying an abnormal heterogenous B cell population in...
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Prototype of a Gaucher disease point-scoring system successfully tested in Finnish patients
A prototype of a Gaucher disease point-scoring system (PSS), originally established by the Gaucher Earlier...
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My Migraine Voice -survey reveals the emotional and social burden of migraine in Finland
Migraine is a disabling headache disorder that places a significant burden both for the patients...
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Specific patient characteristics of heart failure across the LVEF range highlight the importance of effective treatments to reduce hospitalizations
The proportion of patients hospitalized for heart failure (HF) with preserved left ventricular ejection fraction...
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Multimorbidity across multiple ICD-10 codes should be considered when treating migraine patients
In migraine, co-occurrence of two or more diseases or conditions is typical. Asthma and allergies,...
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The Burden of Idiopathic Pulmonary Fibrosis (IPF) in Finland
A new real world evidence study on Idiopathic pulmonary fibrosis (IPF) describes the high disease...
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The Burden Of Chronic Obstructive Pulmonary Disease (COPD) In Finland: Impact Of Disease Severity And Eosinophil Count On Healthcare Resource Utilization
Chronic obstructive pulmonary disease is one of the leading causes of mortality and morbidity worldwide....
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Migraine comorbidity and phenotypic disease networks in occupational health care
The Burden of Migraine Study continues The study ‘Migraine comorbidity and phenotypic disease networks in...
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The burden of adult asthma in Finland: impact of disease severity and eosinophil count on health care resource utilization
Medaffcon’s new real-world evidence study on the burden of adult asthma in Finland demonstrates the...
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Heart failure in Finland: clinical characteristics, mortality, and healthcare resource use
The high mortality rate of heart failure (HF) patients compared to age-matched controls highlights the...
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Migraine nearly doubles the amount of healthcare visits and sick-leave days
New real-world evidence (RWE) based study shows that migraine nearly doubles the amount of healthcare...